ARTERIOSCLEROSE E ATEROSCLEROSE PDF

Katilar Can protein biomarkers provide an index of coronary artery calcification in patients with Type 2 diabetes? Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Dietary fish oils in the prevention and management aterosclsrose cardiovascular and other diseases. Ross R, Harker L.

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Abstract Atherosclerosis, a disease of the large arteries, is the primary cause of heart disease and stroke. Epidemiological studies have revealed several important environmental and genetic risk factors associated with atherosclerosis. Over the past decade, the availability of new investigative tools, including genetically modified mouse models of disease, has resulted in a clearer understanding of the molecular mechanisms that connect altered cholesterol metabolism and other risk factors to the development of atherosclerotic plaque.

It is now clear that atherosclerosis is not simply an inevitable degenerative consequence of ageing, but rather a chronic inflammatory condition that can be converted into an acute clinical event by plaque rupture and thrombosis. Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in the large arteries. The anatomy of a normal artery is shown in Fig.

Because of differences in blood flow dynamics, there are preferred sites of lesion formation within the arteries. Fatty streaks are not clinically significant, but they are the precursors of more advanced lesions characterized by the accumulation of lipid-rich necrotic debris and smooth muscle cells SMCs. Plaques can become increasingly complex, with calcification, ulceration at the luminal surface, and haemorrhage from small vessels that grow into the lesion from the media of the blood vessel wall.

Although advanced lesions can grow sufficiently large to block blood flow, the most important clinical complication is an acute occlusion due to the formation of a thrombus or blood clot, resulting in myocardial infarction or stroke. Usually, the thrombosis is associated with rupture or erosion of the lesion.

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