GASTROPATI NSAID PDF

Salah satu penyebab dari gastropati adalah efek dari NSAID Non steroidal anti inflammatory drugs serta beberapa faktor lain seperti alkohol, stres, ataupun faktor kimiawi. Gastropati NSAID dapat memberikan keluhan dan gambaran klinis yang bervariasi seperti dispepsia, ulkus, erosi, hingga perforasi. Hal ini membuat kemungkinan untuk menyimpulkan bahwa pada pasien dengan rheumatoid arthritis masalah gastrointestinal adalah salah satu komplikasi yang paling sering dari perawatan penyakit. Semua bagian, kecuali sebagian kecil, terletak sebelah kiri garis tengah.

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Gastropathy has many possible causes. Conditions that sometimes lead to gastropathy include: Gastritis Gastritis is inflammation of the lining of your stomach. However, it can also arise from excessive alcohol consumption and certain medications. It can come on slowly or quickly and, when left untreated, may cause stomach ulcers. Gastroparesis is often associated with neurological damage caused by chronic conditions, such as diabetes.

Gastroenteritis Gastroenteritis is another word for a stomach bug or stomach flu. Peptic ulcer A peptic ulcer is a sore that develops on the mucosal lining of your stomach or the upper part of your small intestine, called the duodenum.

Overusing over-the-counter medications, such as aspirin and ibuprofen, can also cause them. Stomach cancer Stomach cancer begins growing in part of your stomach. Most stomach cancers are adenocarcinomas, which start forming in the innermost lining of your stomach. Portal hypertensive gastropathy Portal hypertensive gastropathy PHG is a complication of high blood pressure in your portal veins , which carry blood to your liver.

This disrupts the flow of blood to your stomach lining, leaving it vulnerable to damage. PHG is sometimes related to cirrhosis in your liver. How is it diagnosed? If you have symptoms of gastropathy, there are several tests your doctor can do to help figure out the underlying cause. These include: Endoscopy. Your doctor will use an endoscope , which is a long tube with a camera at the end, to examine the upper part of your digestive system.

Your doctor may take a sample of your breath or stool to examine it for H. Upper gastrointestinal series. This involves taking X-rays after you drink a substance called barium, which is a chalky liquid that helps your doctor see your upper gastrointestinal tract.

Gastric emptying study. Your doctor will place a transducer wand on your abdomen. The wand produces sound waves that a computer turns into images of your digestive system. Endoscopic ultrasound. This involves attaching a transducer wand to an endoscope and feeding it into your stomach through your mouth. This gives a clearer image of your stomach lining. Most causes require lifestyle changes, medication, surgery, or a combination of these. Lifestyle changes Changing some of your daily habits may help you manage the symptoms of your stomach condition.

Your doctor may recommend that you: avoid certain medications, such as aspirin and ibuprofen eat fewer fatty foods reduce your daily salt intake reduce or stop your alcohol consumption drink more water add probiotic foods, such as kimchi and miso, to your diet avoid dairy eat smaller meals several times per day Medication Depending on the cause of your gastropathy, your doctor may recommend prescription or over-the-counter medications.

Some medications work to treat the underlying cause of gastropathy, while others help you manage the symptoms. Medications sometimes involved in gastropathy treatment include:.

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Nonsteroidal anti-inflammatory drug gastropathy.

Gastropati menunjukkan suatu kondisi dimana terjadi kerusakan epitel atau endotel tanpa inflamasi pada mukosa lambung. Hampir Faktor resiko yang mungkin termasuk adalah infeksi oleh H. Kerusakan mukosa secara tropikal terjadi karena NSAID bersifat asam dan lipofili, sehingga mempermudah trapping ion hidrogen masuk mukosa dan menimbulkan kerusakan. Efek sitoproteksi itu dilakukan dengan cara menjaga aliran darah mukosa, meningkatkan sekresi mukosa dan ion bikarbonat dan meningkakan epitel defensif.

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Tinjauan Pustaka : Gastropati NSAID

Resistance of germfree rats to indomethacin-induced intestinal lesions. Several studies have shown that the antipyretic action of NSAIDs is via inhibition of PGE2 synthesis in and near the preoptic hypothalamic area in circumventricular organs [ 31 — 33 ]. Non-steroidal anti-inflammatory drug gastropathy: causes and treatment. The uncoupling of mitochondrial oxidative phosphoryaltion Nsaud these pathophysiological processes, the NSAID-induced inhibition of oxidative phosphorylation in mitochondria is considered as the main underlying mechanism. Derivatives of naproxen, diclofenac, nsajd indomethacin which can release H2S have been reported [ — ]. As a result, the pH at the surface of gastric mucosal epithelial cells normally is maintained in the neutral range when the pH at the gastric luminal surface reaches 1 to 2. Dual antiplatelet therapy with thienopyridine like clopidogrel and NSAID like aspirin is prescribed to decrease adverse cardiac events in patients suffering from acute coronary syndromes or placement of an intracoronary stent [ ], but they are associated gqstropati high risks of GI bleeding [ 21 ].

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gastropati NSAID

Gastropathy has many possible causes. Conditions that sometimes lead to gastropathy include: Gastritis Gastritis is inflammation of the lining of your stomach. However, it can also arise from excessive alcohol consumption and certain medications. It can come on slowly or quickly and, when left untreated, may cause stomach ulcers. Gastroparesis is often associated with neurological damage caused by chronic conditions, such as diabetes.

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Gastropati i magen: Vad är det och hur man behandlar det

Gastrointest Endosc Clin N Am. Nonsteroidal anti-inflammatory drug gastropathy. NSAID gastropathy is characterized by subepithelial hemorrhages, erosions, and ulcers. Although gastric lesions are common at endoscopy, clinically significant problems are uncommon. Subepithelial hemorrhages and erosions may cause minor bleeding, but ulcers must be present for major bleeding, gastric outlet obstruction, or perforation to occur. NSAID use is associated with an increased risk of gastrointestinal complications; this risk is increased with older age, a history of peptic ulcer, a history of gastrointestinal bleeding, higher doses of NSAIDs, and concomitant use of corticosteroids.

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